DOTmed Home MRI Oncology Ultrasound Molecular Imaging X-Ray Cardiology Health IT Business Affairs
News Home Parts & Service Operating Room CT Women's Health Proton Therapy Endoscopy HTMs Mobile Imaging
SEARCH
当前地点:
>
> This Story

starstarstarstarstar (1)
注册记数器 to rate this News Story
Forward Printable StoryPrint Comment

 

MRI Homepage

New research finds brain MR study groups don't reflect U.S. population demographics This must change for large, multicenter studies

What’s new in MR scanners and coils? A review of new innovations arriving on market

Purchasing Insights: The ABCs of buying an MR Facilities must think about their scanning needs of tomorrow when investing today

Siemens gets 7T MR cleared for clinical use in US MAGNETOM Terra offers benefits for neuro and MSK imaging

Contrasting viewpoints on gadolinium Despite evidence of harm, the industry worries about brain retention

MR detects neurological impairments in newborns with CHD before surgery Detects brain impairments even before cardiac surgery

Anthem presses forward with new MR, CT reimbursement guidelines An effort to increase usage of free-standing scan facilities

Merry X-Ray acquires Consensys Imaging Service Expands presence in MR, CT and other imaging modality markets

The future of AI in MR: Supporting clinical decisions Insights from Murat Gungor, vice president of Magnetic Resonance (MR) at Siemens Healthineers North America

MR shielding: out of sight, but hopefully not out of mind Insights from the experts on installation and RF shield maintenance

Computational model of the cortical
and subcortical brain structures that
form the basis of the BrainPrint

Can MR detect Alzheimer's before symptoms have even appeared?

Lauren Dubinsky , Senior Reporter
A team of researchers at Massachusetts General Hospital (MGH) have found a way to spot individuals in the early presymptomatic stages of Alzheimer’s disease with MR. The scans revealed that those with the disease had asymmetrical brain structures in the left and right sides of the brain.

“Compared to the size of a structure, the geometric shape can pick up subtle changes in sub-structures much earlier,” Martin Reuter, lead researcher, told HCB News. “Lateral asymmetries in dementia may have been overlooked for that reason in the past.”

Story Continues Below Advertisement

The (#1 Resource) for Medical Imaging and Peripherals. Call 1-949-273-8000

As a Master Distributor for major brands Barco, Philips, and Sony, we offer custom imaging solutions. With our renowned OEM Solutions and Service/Repair Center, Ampronix is a one-stop shop for HD Medical LCD Displays--Printers--Recorders--4K Cameras



In particular, the asymmetry of the hippocampus and amygdala increases as the disease becomes more severe. The researchers believe the asymmetry of those and a few other structures could be a biomarker for detecting early-stage dementia.

The team developed a computer-aided system called BrainPrint that represents the whole brain based on the shapes, rather than the size or volume, of the structures. An article published in 2015 in the journal, NeuroImage, showed that BrainPrint can be as accurate as a fingerprint in distinguishing individuals.

This new study used BrainPrint to evaluate structural asymmetries in MR images of 700 patients involved in the National Institute of Health-sponsored Alzheimer’s Disease Neuroimaging Initiative (ADNI). The participants received an MR exam at enrollment and then again every six to 12 months, along with cognitive and genetic testing.

The researchers assessed the data from ANDI participants that underwent at least three MR exams. They were then divided into four groups: those diagnosed with probable Alzheimer’s when entering the study, healthy controls with no sign of dementia, those with mild cognitive impairment (MCI) that remained stable over two to three years and those with MCI that progressed to Alzheimer’s.

BrainPrint revealed that differences in the shapes of the hippocampus and amygdala were highest in individuals with dementia and lowest in the healthy controls. Among the group that was diagnosed with MCI, the baseline asymmetry was higher in those that developed Alzheimer’s, and increased even more as symptoms became apparent.

“Clinical Alzheimer’s disease diagnosis occurs very late. By that time decades of advanced neurodegeneration have taken their toll and large portions of the brain are atrophied,” said Reuter. “Recovery at this stage is unlikely, even stopping or significantly slowing the neurodegenerative process at this time will be very difficult.”

If presymptomatic or early-stage individuals at risk of developing the disease are identified, they can be recruited into studies investigating novel therapies, because preventive treatment can still be successful.

Reuter and his team are planning to further explore the relationship between brain asymmetries and established Alzheimer’s disease biomarkers to get a better understanding of the underlying biological mechanisms.

“This approach is a building block for spotting early-stage Alzheimer’s,” he said. ”For high-accuracy Alzheimer’s prediction, genetic markers, other imaging markers, as well as test scores, lifestyle, nutrition, etc., will need to be considered jointly.”

MRI Homepage


You Must Be Logged In To Post A Comment

做广告
提升您的品牌知名度
拍卖+私人销售
获得最好的价格
买设备/配件
找到最低价格
每日新闻
阅读最新信息
目录
浏览所有的DOTmed用户
DOTmed上的伦理
查看我们的伦理计划
金子分开供营商节目
接收PH要求
金子服务经销商节目
接收请求
提供保健服务者
查看所有的HCP(简称医疗保健提供商)的工具
工作/训练
查找/申请工作
Parts Hunter +EasyPay
获取配件报价
最近证明
查看最近通过认证的用户
最近额定
查看最近通过认证的用户
出租中央
租用设备优惠
卖设备/配件
得到最划算
服务技术员论坛
查找帮助和建议
简单的征求建议书
获取设备报价
真正商业展览
查找对设备的服务
对这个站点的通入和用途是受期限和条件我们支配 法律公告 & 保密性通知
物产和业主对 DOTmed.com,公司 Copyright ©2001-2017 DOTmed.com, Inc.
版权所有