"The application of this imaging technique could provide a very early indicator of tumor damage without having to wait for changes in tumor volume, which currently may take months to find out," noted Edward O'Neill, postdoctoral researcher in the department of oncology at MRC Oxford Institute for Radiation Oncology at the University of Oxford in Oxford, United Kingdom. "When using therapeutic response assessment with molecular imaging, making rapid decisions becomes possible, including dose reduction to avoid side effects, assessment of combination therapies, or, in the absence of any measurable response, initiation of palliative options designed toward improving quality of life."
This study was made available online in November 2019 ahead of final publication in print in May 2020.
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The authors of "Imaging DNA Damage Repair In Vivo After 177Lu-DOTATATE Therapy" include Edward O'Neill, Veerle Kersemans, P. Danny Allen, Julia Baguña Torres, Michael Mosely, Sean Smart, Boon Quan Lee, Nadia Falzone, Katherine A. Vallis and Bart Cornelissen, CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom; Samantha Y.A. Terry, Department of Imaging Chemistry and Biology, King's College London, London, United Kingdom; Mark W. Konijnenberg and Marion de Jong, Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands; and Julie Nonnekens, Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands, Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands, and Oncode Institute, Erasmus MC, Rotterdam, The Netherlands.
About the Society of Nuclear Medicine and Molecular Imaging
The Journal of Nuclear Medicine (JNM) is the world's leading nuclear medicine, molecular imaging and theranostics journal, accessed close to 10 million times each year by practitioners around the globe, providing them with the information they need to advance this rapidly expanding field.
JNM is published by the Society of Nuclear Medicine and Molecular Imaging (SNMMI), an international scientific and medical organization dedicated to advancing nuclear medicine and molecular imaging--precision medicine that allows diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes.
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