Looking at further implications of this research, Hagmarker notes, “Current evidence indicates that kidneys can tolerate mean absorbed doses above the general dose-limit. Recent studies have also reported the use of retreatment for patients with progressed disease. If higher renal mean absorbed doses are accepted, higher total activity could be administered, and bone marrow toxicity might become the dose-limiting factor.”

The authors of “Bone Marrow Absorbed Doses and Correlations with Hematologic Response During 177Lu-DOTATATE Treatments Are Influenced by Image-Based Dosimetry Method and Presence of Skeletal Metastases” include Linn Hagmarker, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Tobias Rydén, Martijn van Essen, Peter Gjertsson, and Johanna Svensson, Sahlgrenska University Hospital, Gothenburg, Sweden; Anna Sundlöv, Skåne University Hospital and Lund University, Lund, Sweden; Katarina Sjögreen Gleisner, University of Lund; and Peter Bernhardt, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital Gothenburg, Sweden.

About The Journal of Nuclear Medicine
The Journal of Nuclear Medicine (JNM) is the world’s leading nuclear medicine, molecular imaging and theranostics journal, accessed more than 9 million times each year by practitioners around the globe, providing them with the information they need to advance this rapidly expanding field.

JNM is published by the Society of Nuclear Medicine and Molecular Imaging (SNMMI), an international scientific and medical organization dedicated to advancing nuclear medicine and molecular imaging—precision medicine that allows diagnosis and treatment to be tailored to individual patients in order to achieve the best possible outcomes.

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