Consequently, the research group could construct a valuable multi-site neuroimaging database of 2,409 individuals suffering from multiple psychiatric disorders (ASD: autism spectrum disorder, MDD: major depressive disorder, SCZ: schizophrenia, OCD: obsessive-compulsive disorder, CP: chronic back pain, and several others). This database consists of resting-state fMRI, structural images of the brain, and patient demographics (age, sex, and clinical rating scales) of 125 participants with ASD, 455 participants with MDD, 159 participants with SCZ, 110 participants with OCD, 107 participants with CP, and 42 participants with other disorders as well as 1,421 healthy participants. The researchers released parts of this database to approved users. A person who wants to use this database must download the application form from a website, provide the necessary information, and send it to an e-mail address. After the approval of each application, an ID account is issued. An ID account allows the user to download the data from website. So far, the research group has released the data of 706 participants with psychiatric disorders and 1,122 healthy participants from 8 sites (12 MRI scanners). In addition, the team is currently constructing a publicly open database that anyone can access.

In the future, analyzing such large data by the proposed harmonization method could lead to developing practical brain-circuit-based biomarkers of psychiatric disorders regardless of the imaging site used. This study is thus expected to make a strong contribution to the diagnosis and treatment of psychiatric disorders.


Functional connectivity is quantified by the temporal correlation of resting-state fMRI blood-oxygen-level-dependent signals between pairs of brain regions.

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