Fox and colleagues have previously used the network mapping technique - pioneered by Fox and others - to reveal which parts of the brain are responsible for a number of symptoms, conditions, behavior and even consciousness. Now the method could pave the way to a deeper understanding of Alzheimer's and other brain diseases.
The findings also suggest a unique solution to the "reproducibility crisis" in the field of neuroscience. Reproducibility - the potential for different investigators to run the study again and obtain the same results - is one of the main tenants of the scientific method and critical for translating research findings into treatments. In this study, Fox and colleagues use the human connectome to change the way reproducibility is measured.
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"This is a new way to combine results across many different studies to determine the brain circuit most tightly associated with a given symptom or disease," Fox said. "By shifting our focus from specific brain regions to networks, we show that seemingly inconsistent neuroimaging findings are in fact reproducible."
Juho Joutsa of BIDMC's Berenson-Allen Center for Noninvasive Brain Stimulation and of Massachusetts General Hospital also contributed to this work.
Investigators were supported by funding from the Sidney R. Baer, Jr. Foundation; the National Institutes of Health, (R01 MH113929, K23 NS0837410); the Nancy Lurie Marks Foundation; the Dystonia Medical Research Foundation; the Alzheimer's Association; the BrightFocus Foundation; the Vanderbilt Faculty Research Scholars Award; Academy of Finland and the Finnish Medical Foundation.
About Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center is a patient care, teaching and research affiliate of Harvard Medical School and consistently ranks as a national leader among independent hospitals in National Institutes of Health funding.
BIDMC is in the community with Beth Israel Deaconess Hospital-Milton, Beth Israel Deaconess Hospital-Needham, Beth Israel Deaconess Hospital-Plymouth, Anna Jaques Hospital, Cambridge Health Alliance, Lawrence General Hospital, MetroWest Medical Center, Signature Healthcare, Beth Israel Deaconess HealthCare, Community Care Alliance and Atrius Health. BIDMC is also clinically affiliated with the Joslin Diabetes Center and Hebrew SeniorLife and is a research partner of Dana-Farber/Harvard Cancer Center and the Jackson Laboratory. BIDMC is the official hospital of the Boston Red Sox.
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