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Faster, more accurate sepsis diagnoses could save lives and money

by Gus Iversen, Editor in Chief | January 20, 2015
T2 Biosystems
A new multi-center study suggests that Candida, the most lethal form of sepsis, can be detected in three to five hours using nanotechnology from T2 Biosystems. The traditional blood culture method can take several days, and early detection can significantly reduce an already high mortality rate.

The implications for health care are sizable. According to a statement from T2 Biosystems, Candida currently requires an average of 40 days hospitalization, at the cost of $130,000 per patient. Being able to treat and diagnose faster could lead to shorter stays, lower costs, and fewer deaths. Sepsis costs the U.S. over $20 billion annually.

The two products are the first to utilize T2 magnetic resonance (MR) technology, a proprietary magnetic resonance-based diagnostic technology that performs analysis outside of the body.
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"The ability to determine the presence or absence of Candida within hours — compared to days — is paradigm-changing for patients at risk for these infections," said Dr. Eleftherios Mylonakis, chief of the Division of Infectious Diseases at Rhode Island Hospital, and lead author of the study, in a statement.

A multi-center study published online in the journal Clinical Infectious Diseases (CID) indicates the T2Candida Panel, working in conjunction with the T2Dx Instrument, detects Candida with 91.1 percent sensitivity and 99.4 percent specificity.

That accuracy is particularly significant in the case of intra-abdominal candidiasis, a strain of Candida that is only detected with 38 percent sensitivity using the standard blood culture.

"It will allow us to move from a 'best-guess' approach in treating high-risk patients, such as cancer and transplant patients and patients in the ICU, to a more informed approach where we can quickly direct the best course of therapy, potentially improving patient outcomes and saving lives," said Mylonakis.

The study looked at blood specimens from 1,801 hospitalized patients between 18 and 95 years of age who had a blood culture ordered as part of routine care and returned outcomes in an average of under 4.5 hours.

Both systems were cleared by the FDA last September.

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